Ontology highlight
ABSTRACT:
SUBMITTER: Imamura K
PROVIDER: S-EPMC3457513 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Imamura Kazuhiko K Tsuyama Yoshihito Y Hirata Terukage T Shiraishi Sumihiro S Sakamoto Kazutoshi K Yamada Osamu O Akita Osamu O Shimoi Hitoshi H
Applied and environmental microbiology 20120727 19
WYK-1 is a dipeptidyl peptidase IV inhibitor produced by Aspergillus oryzae strain AO-1. Because WYK-1 is an isoquinoline derivative consisting of three l-amino acids, we hypothesized that a nonribosomal peptide synthetase was involved in its biosynthesis. We identified 28 nonribosomal peptide synthetase genes in the sequenced genome of A. oryzae RIB40. These genes were also identified in AO-1. Among them, AO090001000009 (wykN) was specifically expressed under WYK-1-producing conditions in AO-1. ...[more]