Ontology highlight
ABSTRACT:
SUBMITTER: Park SI
PROVIDER: S-EPMC3457788 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Park Serk In SI Liao Jinhui J Berry Janice E JE Li Xin X Koh Amy J AJ Michalski Megan E ME Eber Matthew R MR Soki Fabiana N FN Sadler David D Sud Sudha S Tisdelle Sandra S Daignault Stephanie D SD Nemeth Jeffrey A JA Snyder Linda A LA Wronski Thomas J TJ Pienta Kenneth J KJ McCauley Laurie K LK
Cancer research 20120501 10
A number of cancers predominantly metastasize to bone, due to its complex microenvironment and multiple types of constitutive cells. Prostate cancer especially has been shown to localize preferentially to bones with higher marrow cellularity. Using an experimental prostate cancer metastasis model, we investigated the effects of cyclophosphamide, a bone marrow-suppressive chemotherapeutic drug, on the development and growth of metastatic tumors in bone. Priming the murine host with cyclophosphami ...[more]