Ontology highlight
ABSTRACT:
SUBMITTER: Ejaz A
PROVIDER: S-EPMC3458075 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Ejaz Asim A Steinmann Eike E Bánki Zoltán Z Anggakusuma Khalid Sana S Lengauer Susanne S Wilhelm Corinne C Zoller Heinz H Schloegl Anna A Steinmann Joerg J Grabski Elena E Kleines Michael M Pietschmann Thomas T Stoiber Heribert H
PloS one 20120925 9
Viruses of different families encode for regulators of the complement system (RCAs) or acquire such RCAs from the host to get protection against complement-mediated lysis (CML). As hepatitis C virus (HCV) shares no genetic similarity to any known RCA and is detectable at high titers in sera of infected individuals, we investigated whether HCV has adapted host-derived RCAs to resist CML. Here we report that HCV selectively incorporates CD59 while neither CD55, nor CD46 are associated with the vir ...[more]