Ontology highlight
ABSTRACT:
SUBMITTER: Larghi P
PROVIDER: S-EPMC3458114 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Larghi Paola P Porta Chiara C Riboldi Elena E Totaro Maria Grazia MG Carraro Lorenzo L Orabona Ciriana C Sica Antonio A
PloS one 20120925 9
Dendritic cells play a central role in keeping the balance between immunity and immune tolerance. A key factor in this equilibrium is the lifespan of DC, as its reduction restrains antigen availability leading to termination of immune responses. Here we show that lipopolysaccharide-driven DC maturation is paralleled by increased nuclear levels of p50 NF-κB, an event associated with DC apoptosis. Lack of p50 in murine DC promoted increased lifespan, enhanced level of maturation associated with in ...[more]