Lesion-based detection of early chemosensitivity using serial static FDG PET/CT in metastatic colorectal cancer.

ABSTRACT:

Purpose

Medical oncology needs early identification of patients that are not responding to systemic therapy. (18)F-Fluorodeoxyglucose (FDG) positron emission tomography (PET) performed before and early during treatment has been proposed for this purpose. However, the best way to assess the change in FDG uptake between two scans has not been identified. We studied cutoff thresholds to identify responding tumours as a function of the method used to measure tumour uptake.

Methods

The study included 28 metastatic colorectal cancer (mCRC) patients who underwent 2 FDG PET/CT scans (baseline and at day 14 of the first course of polychemotherapy). For 78 tumour lesions, 4 standardized uptake value (SUV) indices were measured: maximum SUV (SUV(max)) and mean SUV in a region obtained

SUBMITTER: Buvat I 

PROVIDER: S-EPMC3458195 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature