Research resource: RNA-Seq reveals unique features of the pancreatic ?-cell transcriptome.
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ABSTRACT:
SUBMITTER: Ku GM
PROVIDER: S-EPMC3458219 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
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Research resource: RNA-Seq reveals unique features of the pancreatic β-cell transcriptome.
Ku Gregory M GM Kim Hail H Vaughn Ian W IW Hangauer Matthew J MJ Myung Oh Chang C German Michael S MS McManus Michael T MT
Molecular endocrinology (Baltimore, Md.) 20120821 10
The pancreatic β-cell is critical for the maintenance of glycemic control. Knowing the compendium of genes expressed in β-cells will further our understanding of this critical cell type and may allow the identification of future antidiabetes drug targets. Here, we report the use of next-generation sequencing to obtain nearly 1 billion reads from the polyadenylated RNA of islets and purified β-cells from mice. These data reveal novel examples of β-cell-specific splicing events, promoter usage, an ...[more]
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