Ontology highlight
ABSTRACT:
SUBMITTER: Cooke HA
PROVIDER: S-EPMC3458437 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Cooke Heather A HA Peck Spencer C SC Evans Bradley S BS van der Donk Wilfred A WA
Journal of the American Chemical Society 20120913 38
Methylphosphonate synthase is a non-heme iron-dependent oxygenase that converts 2-hydroxyethylphosphonate (2-HEP) to methylphosphonate. On the basis of experiments with two enantiomers of a substrate analog, 2-hydroxypropylphosphonate, catalysis is proposed to commence with stereospecific abstraction of the pro-S hydrogen on C2 of the substrate. Experiments with isotopologues of 2-HEP indicate stereospecific hydrogen transfer of the pro-R hydrogen at C2 of the substrate to the methyl group of me ...[more]