Ontology highlight
ABSTRACT:
SUBMITTER: Wu H
PROVIDER: S-EPMC3458459 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Wu Huiling H Noordmans Gerda A GA O'Brien Maya R MR Ma Jin J Zhao Cathy Y CY Zhang Geoff Y GY Kwan Tony K T TK Alexander Stephen I SI Chadban Steven J SJ
Journal of the American Society of Nephrology : JASN 20120809 10
Toll-like receptors (TLRs) play a fundamental role in innate immunity and provide a link between innate and adaptive responses to an allograft; however, whether the development of acute and chronic allograft rejection requires TLR signaling is unknown. Here, we studied TLR signaling in a fully MHC-mismatched, life-sustaining murine model of kidney allograft rejection. Mice deficient in the TLR adaptor protein MyD88 developed donor antigen-specific tolerance, which protected them from both acute ...[more]