Ontology highlight
ABSTRACT:
SUBMITTER: Yan Z
PROVIDER: S-EPMC3458521 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Yan Zhenyu Z Shah Parantu K PK Amin Samir B SB Samur Mehmet K MK Huang Norman N Wang Xujun X Misra Vikas V Ji Hongbin H Gabuzda Dana D Li Cheng C
Nucleic acids research 20120529 17
We describe here a novel method for integrating gene and miRNA expression profiles in cancer using feed-forward loops (FFLs) consisting of transcription factors (TFs), miRNAs and their common target genes. The dChip-GemiNI (Gene and miRNA Network-based Integration) method statistically ranks computationally predicted FFLs by their explanatory power to account for differential gene and miRNA expression between two biological conditions such as normal and cancer. GemiNI integrates not only gene an ...[more]