Ontology highlight
ABSTRACT:
SUBMITTER: Ohlenschlager O
PROVIDER: S-EPMC3458545 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Ohlenschläger Oliver O Kuhnert Anja A Schneider Annerose A Haumann Sebastian S Bellstedt Peter P Keller Heidi H Saluz Hans-Peter HP Hortschansky Peter P Hänel Frank F Grosse Frank F Görlach Matthias M Pospiech Helmut H
Nucleic acids research 20120622 17
The RecQL4 helicase is involved in the maintenance of genome integrity and DNA replication. Mutations in the human RecQL4 gene cause the Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes. Mouse models and experiments in human and Xenopus have proven the N-terminal part of RecQL4 to be vital for cell growth. We have identified the first 54 amino acids of RecQL4 (RecQL4_N54) as the minimum interaction region with human TopBP1. The solution structure of RecQL4_N54 was determined by heteronuc ...[more]