Ontology highlight
ABSTRACT:
SUBMITTER: Choi YH
PROVIDER: S-EPMC3458570 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Nucleic acids research 20120626 17
The telomere integrity is maintained via replication machinery, telomere associated proteins and telomerase. Many telomere associated proteins are regulated in a cell cycle-dependent manner. Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1), a single-stranded oligonucleotide binding protein, is thought to play a pivotal role in telomere maintenance. Here, we identified hnRNP A1 as a novel substrate for vaccinia-related kinase 1 (VRK1), a cell cycle regulating kinase. Phosphorylation by VRK1 ...[more]