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Recyclable fluorous cinchona alkaloid ester as a chiral promoter for asymmetric fluorination of ?-ketoesters.

ABSTRACT: A fluorous cinchona alkaloid ester has been developed as a chiral promoter for the asymmetric fluorination of ?-ketoesters. It has comparable reactivity and selectivity to the nonfluorous versions of cinchona alkaloids and can be easily recovered from the reaction mixture by simple fluorous solid-phase extraction (F-SPE) and used for the next round of reaction without further purification.

SUBMITTER: Yi WB

PROVIDER: S-EPMC3458743 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Recyclable fluorous cinchona alkaloid ester as a chiral promoter for asymmetric fluorination of β-ketoesters.

Yi Wen-Bin WB Huang Xin X Zhang Zijuan Z Zhu Dian-Rong DR Cai Chun C Zhang Wei W

Beilstein journal of organic chemistry 20120803

A fluorous cinchona alkaloid ester has been developed as a chiral promoter for the asymmetric fluorination of β-ketoesters. It has comparable reactivity and selectivity to the nonfluorous versions of cinchona alkaloids and can be easily recovered from the reaction mixture by simple fluorous solid-phase extraction (F-SPE) and used for the next round of reaction without further purification. ...[more]

PMID: 23019453

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