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Asymmetric organocatalytic decarboxylative Mannich reaction using ?-keto acids: A new protocol for the synthesis of chiral ?-amino ketones.


ABSTRACT: The first decarboxylative Mannich reaction employing ?-keto acids, catalyzed by cinchonine-derived bifunctional thiourea catalyst has been described. The desired ?-amino ketones were obtained in excellent yields and with moderate to good enantioselectivities.

SUBMITTER: Jiang C 

PROVIDER: S-EPMC3458749 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Asymmetric organocatalytic decarboxylative Mannich reaction using β-keto acids: A new protocol for the synthesis of chiral β-amino ketones.

Jiang Chunhui C   Zhong Fangrui F   Lu Yixin Y  

Beilstein journal of organic chemistry 20120813


The first decarboxylative Mannich reaction employing β-keto acids, catalyzed by cinchonine-derived bifunctional thiourea catalyst has been described. The desired β-amino ketones were obtained in excellent yields and with moderate to good enantioselectivities. ...[more]

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