Ontology highlight
ABSTRACT:
SUBMITTER: Cochrane JR
PROVIDER: S-EPMC3458759 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Cochrane James R JR Yoon Dong Hee DH McErlean Christopher S P CS Jolliffe Katrina A KA
Beilstein journal of organic chemistry 20120821
The cyclic peptide core of the antifungal and antibiotic cyclic depsipeptide LI-F04a was synthesised by using a modified Yamaguchi macrolactonization approach. Alternative methods of macrolactonization (e.g., Corey-Nicolaou) resulted in significant epimerization of the C-terminal amino acid during the cyclization reaction. The D-stereochemistry of the alanine residue in the naturally occurring cyclic peptide may be required for the antifungal activity of this natural product. ...[more]