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Expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization.

ABSTRACT: A mild and practical synthesis of spirooxindole [1,3]oxazino derivatives from N-substituted isatins and 1,3-dicarbonyl compounds with pyridine derivatives is reported. The reactions provided good to excellent yields. Further exploration of the molecular diversity of these compounds is demonstrated through Diels-Alder reactions.

SUBMITTER: Dai C

PROVIDER: S-EPMC3458780 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization.

Dai Chunhui C Liang Bo B Stephenson Corey R J CR

Beilstein journal of organic chemistry 20120702

A mild and practical synthesis of spirooxindole [1,3]oxazino derivatives from N-substituted isatins and 1,3-dicarbonyl compounds with pyridine derivatives is reported. The reactions provided good to excellent yields. Further exploration of the molecular diversity of these compounds is demonstrated through Diels-Alder reactions. ...[more]

PMID: 23019426

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