Alcohol-induced plasticity in the dynorphin/kappa-opioid receptor system.
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ABSTRACT:
SUBMITTER: Sirohi S
PROVIDER: S-EPMC3459013 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Alcohol-induced plasticity in the dynorphin/kappa-opioid receptor system.
Sirohi Sunil S Bakalkin Georgy G Walker Brendan M BM
Frontiers in molecular neuroscience 20120927
Alcoholism is a chronic relapsing disorder characterized by continued alcohol use despite numerous adverse consequences. Alcohol has been shown to interact with numerous neurotransmitter systems to exert its pharmacological effects. The endogenous opioid system (EOS) has been strongly implicated in the positive and negative reinforcing effects of alcohol. Traditionally recognized as dysphoric/anhedonic in nature, the dynorphin/kappa-opioid receptor (DYN/KOR) system has recently received consider ...[more]
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