Ontology highlight
ABSTRACT:
SUBMITTER: Song JH
PROVIDER: S-EPMC3459262 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Song Jin H JH Kandasamy Karthikeyan K Zemskova Marina M Lin Ying-Wei YW Kraft Andrew S AS
Cancer research 20101116 2
ABT-737, a small molecule cell-permeable Bcl-2 antagonist that acts by mimicking BH3 proteins, induces apoptotic cell death in multiple cancer types. However, when incubated with this agent many solid tumor cell lines do not undergo apoptosis. The current study reveals a novel mechanism whereby ABT-737 when added to apoptosis-resistant cancer cells has profound biologic effects. In PV-10 cells, a renal cell carcinoma that does not die after ABT-737 treatment, this agent induces a two-fold change ...[more]