Circulating microRNA is a biomarker of biliary atresia.
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ABSTRACT: Objective
The lack of reliable noninvasive diagnostic biomarkers of biliary atresia (BA) results in delayed diagnosis and worsened patient outcome. Circulating microRNAs (miRNAs) are a new class of noninvasive biomarkers with encouraging diagnostic utility.Methods
We examined the ability of serum miRNAs to distinguish BA from other forms of neonatal hyperbilirubinemia. BA-specific serum miRNAs were identified using a microfluidic array platform and validated in a larger, independent sample set.Results
The miR-200b/429 cluster was significantly increased in the sera of patients with BA relative to infants with non-BA cholestatic disorders.Conclusions
Circulating levels of the miR-200b/429 cluster are elevated in infants with BA and have promising diagnostic clinical performance.
SUBMITTER: Zahm AM
PROVIDER: S-EPMC3459263 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Publications
Circulating microRNA is a biomarker of biliary atresia.
Zahm Adam M AM Hand Nicholas J NJ Boateng LaTasha A LA Friedman Joshua R JR
Journal of pediatric gastroenterology and nutrition 20121001 4
<h4>Objective</h4>The lack of reliable noninvasive diagnostic biomarkers of biliary atresia (BA) results in delayed diagnosis and worsened patient outcome. Circulating microRNAs (miRNAs) are a new class of noninvasive biomarkers with encouraging diagnostic utility.<h4>Methods</h4>We examined the ability of serum miRNAs to distinguish BA from other forms of neonatal hyperbilirubinemia. BA-specific serum miRNAs were identified using a microfluidic array platform and validated in a larger, independ ...[more]
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