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Palladium-catalyzed 1,1-difunctionalization of ethylene.

ABSTRACT: The 1,1-difunctionalization of ethylene, with aryl/vinyl/heteroaryl transmetalating agents and vinyl electrophiles, is reported. The reaction is high-yielding under a low pressure of ethylene, and regioselectivity is generally high for the 1,1-disubstituted product. The process is highlighted by the use of heteroaromatic cross-coupling reagents, which have not been competent reaction partners in previously reported efforts.

SUBMITTER: Saini V

PROVIDER: S-EPMC3459322 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

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Palladium-catalyzed 1,1-difunctionalization of ethylene.

Saini Vaneet V Sigman Matthew S MS

Journal of the American Chemical Society 20120710 28

The 1,1-difunctionalization of ethylene, with aryl/vinyl/heteroaryl transmetalating agents and vinyl electrophiles, is reported. The reaction is high-yielding under a low pressure of ethylene, and regioselectivity is generally high for the 1,1-disubstituted product. The process is highlighted by the use of heteroaromatic cross-coupling reagents, which have not been competent reaction partners in previously reported efforts. ...[more]

PMID: 22765909

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