Induction and molecular signature of pathogenic TH17 cells.
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ABSTRACT:
SUBMITTER: Lee Y
PROVIDER: S-EPMC3459594 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Publications
Induction and molecular signature of pathogenic TH17 cells.
Lee Youjin Y Awasthi Amit A Yosef Nir N Quintana Francisco J FJ Xiao Sheng S Peters Anneli A Wu Chuan C Kleinewietfeld Markus M Kunder Sharon S Hafler David A DA Sobel Raymond A RA Regev Aviv A Kuchroo Vijay K VK
Nature immunology 20120909 10
Interleukin 17 (IL-17)-producing helper T cells (T(H)17 cells) are often present at the sites of tissue inflammation in autoimmune diseases, which has led to the conclusion that T(H)17 cells are main drivers of autoimmune tissue injury. However, not all T(H)17 cells are pathogenic; in fact, T(H)17 cells generated with transforming growth factor-β1 (TGF-β1) and IL-6 produce IL-17 but do not readily induce autoimmune disease without further exposure to IL-23. Here we found that the production of T ...[more]
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