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Primary central nervous system angiosarcoma: two case reports.


ABSTRACT: Primary angiosarcoma of the brain is extremely rare; only 15 cases have been reported in adults over the last 25 years.We describe two cases of primary angiosarcoma of the brain that are well characterized by imaging, histopathology, and immunohistochemistry. Case 1: our first patient was a 35-year-old woman who developed exophthalmos. Subtotal resection of a left extra-axial retro-orbital mass was performed. Case 2: our second patient was a 47-year-old man who presented to our facility with acute visual loss, word-finding difficulty and subtle memory loss. A heterogeneously-enhancing left sphenoid wing mass was removed. We also review the literature aiming at developing a rational approach to diagnosis and treatment, given the rarity of this entity.Gross total resection is the standard of care for primary angiosarcoma of the brain. Adjuvant radiation and chemotherapy are playing increasingly recognized roles in the therapy of these rare tumors.

SUBMITTER: Hackney JR 

PROVIDER: S-EPMC3459733 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature

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Primary central nervous system angiosarcoma: two case reports.

Hackney James R JR   Palmer Cheryl Ann CA   Riley Kristen O KO   Cure Joel K JK   Fathallah-Shaykh Hassan M HM   Nabors Louis B LB  

Journal of medical case reports 20120821


<h4>Introduction</h4>Primary angiosarcoma of the brain is extremely rare; only 15 cases have been reported in adults over the last 25 years.<h4>Case presentations</h4>We describe two cases of primary angiosarcoma of the brain that are well characterized by imaging, histopathology, and immunohistochemistry. Case 1: our first patient was a 35-year-old woman who developed exophthalmos. Subtotal resection of a left extra-axial retro-orbital mass was performed. Case 2: our second patient was a 47-yea  ...[more]

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