Ontology highlight
ABSTRACT:
SUBMITTER: Magger O
PROVIDER: S-EPMC3459874 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
PLoS computational biology 20120927 9
The prioritization of candidate disease-causing genes is a fundamental challenge in the post-genomic era. Current state of the art methods exploit a protein-protein interaction (PPI) network for this task. They are based on the observation that genes causing phenotypically-similar diseases tend to lie close to one another in a PPI network. However, to date, these methods have used a static picture of human PPIs, while diseases impact specific tissues in which the PPI networks may be dramatically ...[more]