Ontology highlight
ABSTRACT:
SUBMITTER: Shpargel KB
PROVIDER: S-EPMC3459986 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Shpargel Karl B KB Sengoku Toru T Yokoyama Shigeyuki S Magnuson Terry T
PLoS genetics 20120927 9
UTX (KDM6A) and UTY are homologous X and Y chromosome members of the Histone H3 Lysine 27 (H3K27) demethylase gene family. UTX can demethylate H3K27; however, in vitro assays suggest that human UTY has lost enzymatic activity due to sequence divergence. We produced mouse mutations in both Utx and Uty. Homozygous Utx mutant female embryos are mid-gestational lethal with defects in neural tube, yolk sac, and cardiac development. We demonstrate that mouse UTY is devoid of in vivo demethylase activi ...[more]