High dose vitamin D therapy for chronic pain in children and adolescents with sickle cell disease: results of a randomized double blind pilot study.
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SUBMITTER: Osunkwo I
PROVIDER: S-EPMC3460143 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
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High dose vitamin D therapy for chronic pain in children and adolescents with sickle cell disease: results of a randomized double blind pilot study.
Osunkwo Ifeyinwa I Ziegler Thomas R TR Alvarez Jessica J McCracken Courtney C Cherry Korin K Osunkwo Chinyere E CE Ofori-Acquah Solomon F SF Ghosh Samit S Ogunbobode Adeolu A Rhodes Jim J Eckman James R JR Dampier Carlton C Tangpricha Vin V
British journal of haematology 20120828 2
We report results of a pilot study of high-dose vitamin D in sickle cell disease (SCD). Subjects were given a 6-week course of oral high-dose cholecalciferol (4000-100 000 IU per week) or placebo and monitored prospectively for a period of six months. Vitamin D insufficiency and deficiency was present at baseline in 82·5% and 52·5% of subjects, respectively. Subjects who received high-dose vitamin D achieved higher serum 25-hydroxyvitamin D, experienced fewer pain days per week, and had higher p ...[more]
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