Ontology highlight
ABSTRACT:
SUBMITTER: Anders S
PROVIDER: S-EPMC3460195 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Anders Simon S Reyes Alejandro A Huber Wolfgang W
Genome research 20120621 10
RNA-seq is a powerful tool for the study of alternative splicing and other forms of alternative isoform expression. Understanding the regulation of these processes requires sensitive and specific detection of differential isoform abundance in comparisons between conditions, cell types, or tissues. We present DEXSeq, a statistical method to test for differential exon usage in RNA-seq data. DEXSeq uses generalized linear models and offers reliable control of false discoveries by taking biological ...[more]