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Anti-Phosphatidylserine-Prothrombin Antibodies are Associated with Outcome in a TIA Cohort.


ABSTRACT: BACKGROUND:Antiphospholipid antibodies (aPLs) have been associated with thrombosis in the antiphospholipid antibody syndrome (APS) and with atherosclerotic vascular events in patients without APS. We examined the significance of aPLs in transient ischemic attack (TIA). PATIENTS/METHODS:Patients with TIA <48?h from symptom onset were prospectively enrolled. Traditional aPLs, including anticardiolipin and ?2-glycoprotein-I (?2GPI), and newer aPLs, including anti-phosphatidylserine/prothrombin (aPS/PT), ?2GPI Domain 4/5 and ?2GPI Domain 1 were measured. Primary outcome was a composite of stroke or death within 90?days or identification of a high risk stroke mechanism. Secondary outcomes were stroke or death and the presence of clinical/sub-clinical atherosclerosis. RESULTS:Over 4.5?years, 167 patients were enrolled. Forty one patients (25%) had the composite endpoint. Antibodies were measured in 158 subjects. aPS/PT IgG antibodies were significantly associated with stroke/death (OR 16.3, 95% CI 2.3-116.7, p?=?0.005) and were non-significantly associated with the composite endpoint (OR 4.7, 95% CI 0.8-29.2, p?=?0.10). In multivariate analysis adjusting for ABCD(2) risk score, aPS/PT IgG remained associated with stroke/death (OR 15.7, 95% CI 2.0-125.6, p?=?0.009). Other aPLs were not associated with clinical outcome and no association between APLs and atherosclerosis was identified. CONCLUSION:In contrast to other aPLs, aPS/PT IgG antibodies are independently associated with stroke or death in patients with TIA.

SUBMITTER: Mullen MT 

PROVIDER: S-EPMC3460224 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Anti-Phosphatidylserine-Prothrombin Antibodies are Associated with Outcome in a TIA Cohort.

Mullen Michael T MT   Messé Steven R SR   Kasner Scott E SE   Sansing Lauren L   Husain M R MR   Norman Gary L GL   Shums Zakera Z   Cucchiara Brett L BL  

Frontiers in neurology 20120928


<h4>Background</h4>Antiphospholipid antibodies (aPLs) have been associated with thrombosis in the antiphospholipid antibody syndrome (APS) and with atherosclerotic vascular events in patients without APS. We examined the significance of aPLs in transient ischemic attack (TIA).<h4>Patients/methods</h4>Patients with TIA <48 h from symptom onset were prospectively enrolled. Traditional aPLs, including anticardiolipin and β2-glycoprotein-I (β2GPI), and newer aPLs, including anti-phosphatidylserine/p  ...[more]

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