Ontology highlight
ABSTRACT:
SUBMITTER: Richards S
PROVIDER: S-EPMC3461084 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Richards Sue S Pui Ching-Hon CH Gayon Paul P
Pediatric blood & cancer 20120612 2
Treatment of the central nervous system (CNS) is an essential therapy component for childhood acute lymphoblastic leukemia (ALL). Individual patient data from 47 trials addressing 16 CNS treatment comparisons were analyzed. Event-free survival (EFS) was similar for radiotherapy versus intrathecal (IT), and radiotherapy plus IT versus IV methotrexate (IV MTX) plus IT. Triple intrathecal therapy (TIT) gave similar EFS but poorer survival than intrathecal methotrexate (IT MTX), but additional IV MT ...[more]