Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice.
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ABSTRACT:
SUBMITTER: Rossi L
PROVIDER: S-EPMC3461270 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Publications
Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice.
Rossi Lara L Lin Kuanyin K KK Boles Nathan C NC Yang Liubin L King Katherine Y KY Jeong Mira M Mayle Allison A Goodell Margaret A MA
Cell stem cell 20120901 3
Hematopoietic stem cells (HSCs) represent one of the first recognized somatic stem cell types. As such, nearly 200 genes have been examined for roles in HSC function in knockout mice. In this review, we compile the majority of these reports to provide a broad overview of the functional modules revealed by these genetic analyses and highlight some key regulatory pathways involved, including cell cycle control, Tgf-β signaling, Pten/Akt signaling, Wnt signaling, and cytokine signaling. Finally, we ...[more]
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