Ontology highlight
ABSTRACT:
SUBMITTER: Perrot A
PROVIDER: S-EPMC3461705 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Perrot A A Pionneau C C Azar N N Baillou C C Lemoine F M FM Leblond V V Merle-Béral H H Béné M-C MC Herbrecht R R Bahram S S Vallat L L
Blood cancer journal 20120907
Waldenström's macroglobulinemia (WM) is a clonal B-cell lymphoproliferative disorder (LPD) of post-germinal center nature. Despite the fact that the precise molecular pathway(s) leading to WM remain(s) to be elucidated, a hallmark of the disease is the absence of the immunoglobulin heavy chain class switch recombination. Using two-dimensional gel electrophoresis, we compared proteomic profiles of WM cells with that of other LPDs. We were able to demonstrate that WM constitutes a unique proteomic ...[more]