Ontology highlight
ABSTRACT:
SUBMITTER: Weiss A
PROVIDER: S-EPMC3461928 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Weiss Andreas A Träger Ulrike U Wild Edward J EJ Grueninger Stephan S Farmer Ruth R Landles Christian C Scahill Rachael I RI Lahiri Nayana N Haider Salman S Macdonald Douglas D Frost Chris C Bates Gillian P GP Bilbe Graeme G Kuhn Rainer R Andre Ralph R Tabrizi Sarah J SJ
The Journal of clinical investigation 20120917 10
Huntington's disease (HD) is a fatal, inherited neurodegenerative disorder caused by an expanded CAG repeat in the gene encoding huntingtin (HTT). Therapeutic approaches to lower mutant HTT (mHTT) levels are expected to proceed to human trials, but noninvasive quantification of mHTT is not currently possible. The importance of the peripheral immune system in neurodegenerative disease is becoming increasingly recognized. Peripheral immune cells have been implicated in HD pathogenesis, but HTT lev ...[more]