Ontology highlight
ABSTRACT:
SUBMITTER: Tullin S
PROVIDER: S-EPMC3462199 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Tullin Søren S Sams Anette A Brandt Jakob J Dahl Kirsten K Gong Wei W Jeppesen Claus Bekker CB Krogh Thomas Nylandsted TN Olsen Grith Skytte GS Liu Yun Y Pedersen Anette Amstrup AA Petersen Jørn Meidahl JM Rolin Bidda B Wahlund Per-Olof PO Kalthoff Christoph C
PloS one 20121001 10
<h4>Aims/hypothesis</h4>Several studies have shown that adiponectin can lower blood glucose in diabetic mice. The aim of this study was to establish an effective adiponectin production process and to evaluate the anti-diabetic potential of the different adiponectin forms in diabetic mice and sand rats.<h4>Methods</h4>Human high molecular weight, mouse low molecular weight and mouse plus human globular adiponectin forms were expressed and purified from mammalian cells or yeast. The purified prote ...[more]