Ontology highlight
ABSTRACT:
SUBMITTER: Spisak S
PROVIDER: S-EPMC3462205 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Spisák Sándor S Kalmár Alexandra A Galamb Orsolya O Wichmann Barna B Sipos Ferenc F Péterfia Bálint B Csabai István I Kovalszky Ilona I Semsey Szabolcs S Tulassay Zsolt Z Molnár Béla B
PloS one 20121001 10
Tumorigenesis is accompanied by changes in the DNA methylation pattern. Our aim was to test a novel approach for identification of transcripts at whole transcript level which are regulated by DNA methylation. Our approach is based on comparison of data obtained from transcriptome profiling of primary human samples and in vitro cell culture models. Epithelial cells were collected by LCM from normal, adenoma, and tumorous colonic samples. Using gene expression analysis, we identified downregulated ...[more]