Ontology highlight
ABSTRACT:
SUBMITTER: Hehir S
PROVIDER: S-EPMC3462273 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Hehir Sarah S Plourde Nicole M NM Gu Li L Poree Dawanne E DE Welsh William J WJ Moghe Prabhas V PV Uhrich Kathryn E KE
Acta biomaterialia 20120724 11
Amphiphilic macromolecules (AMs) based on carbohydrate domains functionalized with poly(ethylene glycol) can inhibit the uptake of oxidized low density lipoprotein (oxLDL) mediated by scavenger receptor A (SR-A) and counteract foam cell formation, the characteristic "atherosclerotic" phenotype. A series of AMs was prepared by altering the carbohydrate chemistry to evaluate the influence of backbone architecture on the physicochemical and biological properties. Upon evaluating the degree of polym ...[more]