Engineering of therapeutic polypeptides through chemical synthesis: early lessons from human parathyroid hormone and analogues.
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ABSTRACT:
SUBMITTER: Dong S
PROVIDER: S-EPMC3462362 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
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Engineering of therapeutic polypeptides through chemical synthesis: early lessons from human parathyroid hormone and analogues.
Dong Suwei S Shang Shiying S Li Jianfeng J Tan Zhongping Z Dean Thomas T Maeda Akira A Gardella Thomas J TJ Danishefsky Samuel J SJ
Journal of the American Chemical Society 20120829 36
Application of chemical synthesis to gain access to high purity hPTH as well as more stable analogues was accomplished through a menu of extended NCL followed by metal free dethiylation. ...[more]
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