Effects of hapten density on the induced antibody repertoire.
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ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC3462448 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Publications
Effects of hapten density on the induced antibody repertoire.
Li Qian Q Rodriguez Luis G LG Farnsworth David F DF Gildersleeve Jeffrey C JC
Chembiochem : a European journal of chemical biology 20100801 12
Small peptides and oligosaccharides are important antigens for the development of vaccines and the production of monoclonal antibodies. Because of their small size, peptides and oligosaccharides are non-immunogenic on their own and typically must be conjugated to a larger carrier protein to elicit an immune response. Selection of a suitable carrier protein, conjugation method, and hapten density are critical for generating an optimal immune response. We used a glycan array to compare the reperto ...[more]
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