Ontology highlight
ABSTRACT:
SUBMITTER: Qian W
PROVIDER: S-EPMC3462889 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Qian Wenjian W Park Jung-Eun JE Liu Fa F Lee Kyung S KS Burke Terrence R TR
Bioorganic & medicinal chemistry 20120526 14
Protein-protein interactions (PPIs) mediated by the polo-box domain (PBD) of polo-like kinase 1 (Plk1) serve important roles in cell proliferation. Critical elements in the high affinity recognition of peptides and proteins by PBD are derived from pThr/pSer-residues in the binding ligands. However, there has been little examination of pThr/pSer mimetics within a PBD context. Our current paper compares the abilities of a variety of amino acid residues and derivatives to serve as pThr/pSer replace ...[more]