Effect of statins on skeletal muscle: exercise, myopathy, and muscle outcomes.

ABSTRACT: Statins are effective in reducing low-density lipoprotein cholesterol and cardiac events but can produce muscle side effects. We have hypothesized that statin-related muscle complaints are exacerbated by exercise and influenced by factors including mitochondrial dysfunction, membrane disruption, and/or calcium handling. The interaction between statins, exercise, and muscle symptoms may be more effectively diagnosed and treated as rigorous scientific studies accumulate.

SUBMITTER: Parker BA 

PROVIDER: S-EPMC3463373 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature