Ontology highlight
ABSTRACT:
SUBMITTER: Hwang W
PROVIDER: S-EPMC3463606 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Hwang Woochang W Hackler Laszlo L Wu George G Ji Hongkai H Zack Donald J DJ Qian Jiang J
PloS one 20121003 10
Understanding gene regulation is crucial to dissect the molecular basis of human development and disease. Previous studies on transcription regulatory networks often focused on their static properties. Here we used retinal development as a model system to investigate the dynamics of regulatory networks that are comprised of transcription factors, microRNAs and other protein-coding genes. We found that the active sub-networks are topologically different at early and late stages of retinal develop ...[more]