Binding of a tritiated inverse agonist to cannabinoid CB1 receptors is increased in patients with schizophrenia.
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ABSTRACT:
SUBMITTER: Jenko KJ
PROVIDER: S-EPMC3463751 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
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Binding of a tritiated inverse agonist to cannabinoid CB1 receptors is increased in patients with schizophrenia.
Jenko Kimberly J KJ Hirvonen Jussi J Henter Ioline D ID Anderson Kacey B KB Zoghbi Sami S SS Hyde Thomas M TM Deep-Soboslay Amy A Innis Robert B RB Kleinman Joel E JE
Schizophrenia research 20120819 2-3
This study sought to determine whether cannabinoid-1 (CB(1)) receptor binding was altered in the postmortem dorsolateral prefrontal cortex (DLPFC) of individuals with schizophrenia (schizophrenia; n=47) compared to controls (n=43). The CB(1) receptor inverse agonist radioligand [(3)H]MePPEP was used to measure specific binding to CB(1) receptors. The specific binding of [(3)H]MePPEP to CB(1) receptors was 20% higher in patients with schizophrenia than in controls. Power analyses suggested that 5 ...[more]
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