Ontology highlight
ABSTRACT:
SUBMITTER: Chang CS
PROVIDER: S-EPMC3464115 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Chang Christie S CS Clarke Astrid A Pillus Lorraine L
G3 (Bethesda, Md.) 20121001 10
The acetyltransferase Esa1 is essential in the yeast Saccharomyces cerevisiae and plays a critical role in multiple cellular processes. The most well-defined targets for Esa1 are lysine residues on histones. However, an increasing number of nonhistone proteins have recently been identified as substrates of Esa1. In this study, four genes (LYS20, LEU2, VAP1, and NAB3) were identified in a genetic screen as high-copy suppressors of the conditional temperature-sensitive lethality of an esa1 mutant. ...[more]