Ontology highlight
ABSTRACT:
SUBMITTER: Chatterjee R
PROVIDER: S-EPMC3464117 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Chatterjee Raghunath R Zhao Jianfei J He Ximiao X Shlyakhtenko Andrey A Mann Ishminder I Waterfall Joshua J JJ Meltzer Paul P Sathyanarayana B K BK FitzGerald Peter C PC Vinson Charles C
G3 (Bethesda, Md.) 20121001 10
Previously, we identified 8-bps long DNA sequences (8-mers) that localize in human proximal promoters and grouped them into known transcription factor binding sites (TFBS). We now examine split 8-mers consisting of two 4-mers separated by 1-bp to 30-bps (X(4)-N(1-30)-X(4)) to identify pairs of TFBS that localize in proximal promoters at a precise distance. These include two overlapping TFBS: the ETS⇔ETS motif ((C/G)CCGGAAGCGGAA) and the ETS⇔CRE motif ((C/G)CGGAAGTGACGTCAC). The nucleotides in bo ...[more]