Structural synaptic elements are differentially regulated in superior temporal cortex of schizophrenia patients.
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ABSTRACT:
SUBMITTER: Schmitt A
PROVIDER: S-EPMC3464383 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
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Structural synaptic elements are differentially regulated in superior temporal cortex of schizophrenia patients.
Schmitt Andrea A Leonardi-Essmann Fernando F Durrenberger Pascal F PF Wichert Sven P SP Spanagel Rainer R Arzberger Thomas T Kretzschmar Hans H Zink Mathias M Herrera-Marschitz Mario M Reynolds Richard R Rossner Moritz J MJ Falkai Peter P Gebicke-Haerter Peter J PJ
European archives of psychiatry and clinical neuroscience 20120323 7
Inaccurate wiring and synaptic pathology appear to be major hallmarks of schizophrenia. A variety of gene products involved in synaptic neurotransmission and receptor signaling are differentially expressed in brains of schizophrenia patients. However, synaptic pathology may also develop by improper expression of intra- and extra-cellular structural elements weakening synaptic stability. Therefore, we have investigated transcription of these elements in the left superior temporal gyrus of 10 schi ...[more]
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