Ontology highlight
ABSTRACT:
SUBMITTER: Feng Y
PROVIDER: S-EPMC3464449 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Feng Youjun Y Cao Min M Shi Jie J Zhang Huimin H Hu Dan D Zhu Jing J Zhang Xianyun X Geng Meiling M Zheng Feng F Pan Xiuzhen X Li Xianfu X Hu Fuquan F Tang Jiaqi J Wang Changjun C
Scientific reports 20121005
NeuB, a sialic acid synthase catalyzes the last committed step of the de novo biosynthetic pathway of sialic acid, a major element of bacterial surface structure. Here we report a functional NeuB homologue of Streptococcus suis, a zoonotic agent, and systematically address its molecular and immunological role in bacterial virulence. Disruption of neuB led to thinner capsules and more susceptibility to pH, and cps2B inactivation resulted in complete absence of capsular polysaccharides. These two ...[more]