Ontology highlight
ABSTRACT:
SUBMITTER: Koizumi S
PROVIDER: S-EPMC3464483 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Koizumi Schuichi S Shigemoto-Mogami Yukari Y Nasu-Tada Kaoru K Shinozaki Yoichi Y Ohsawa Keiko K Tsuda Makoto M Joshi Bhalchandra V BV Jacobson Kenneth A KA Kohsaka Shinichi S Inoue Kazuhide K
Nature 20070404 7139
Microglia, brain immune cells, engage in the clearance of dead cells or dangerous debris, which is crucial to the maintenance of brain functions. When a neighbouring cell is injured, microglia move rapidly towards it or extend a process to engulf the injured cell. Because cells release or leak ATP when they are stimulated or injured, extracellular nucleotides are thought to be involved in these events. In fact, ATP triggers a dynamic change in the motility of microglia in vitro and in vivo, a pr ...[more]