Ontology highlight
ABSTRACT:
SUBMITTER: Mertens HD
PROVIDER: S-EPMC3464537 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20120815 41
The urokinase-type plasminogen activator receptor (uPAR) provides a rendezvous between proteolytic degradation of the extracellular matrix and integrin-mediated adhesion to vitronectin. These processes are, however, tightly linked because the high affinity binding of urokinase regulates the binding of uPAR to matrix-embedded vitronectin. Although crystal structures exist to define the corresponding static bi- and trimolecular receptor complexes, it is evident that the dynamic property of uPAR pl ...[more]