Ontology highlight
ABSTRACT:
SUBMITTER: Carpenter MA
PROVIDER: S-EPMC3464582 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Carpenter Michael A MA Li Ming M Rathore Anurag A Lackey Lela L Law Emily K EK Land Allison M AM Leonard Brandon B Shandilya Shivender M D SM Bohn Markus-Frederik MF Schiffer Celia A CA Brown William L WL Harris Reuben S RS
The Journal of biological chemistry 20120815 41
Multiple studies have indicated that the TET oxidases and, more controversially, the activation-induced cytidine deaminase/APOBEC deaminases have the capacity to convert genomic DNA 5-methylcytosine (MeC) into altered nucleobases that provoke excision repair and culminate in the replacement of the original MeC with a normal cytosine (C). We show that human APOBEC3A (A3A) efficiently deaminates both MeC to thymine (T) and normal C to uracil (U) in single-stranded DNA substrates. In comparison, th ...[more]