Ontology highlight
ABSTRACT:
SUBMITTER: Voigt K
PROVIDER: S-EPMC3464645 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Voigt Katrin K Gogol-Döring Andreas A Miskey Csaba C Chen Wei W Cathomen Toni T Izsvák Zsuzsanna Z Ivics Zoltán Z
Molecular therapy : the journal of the American Society of Gene Therapy 20120710 10
The Sleeping Beauty (SB) transposon is a nonviral, integrating vector system with proven efficacy in preclinical animal models, and thus holds promise for future clinical applications. However, SB has a close-to-random insertion profile that could lead to genotoxic effects, thereby presenting a potential safety issue. We evaluated zinc finger (ZF) DNA-binding domains (DBDs) for their abilities to introduce a bias into SB's insertion profile. E2C, that binds a unique site in the erbB-2 gene, medi ...[more]