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Significant pharmacokinetic interactions between artemether/lumefantrine and efavirenz or nevirapine in HIV-infected Ugandan adults.


ABSTRACT: Co-administration of artemether/lumefantrine with antiretroviral therapy has potential for pharmacokinetic drug interactions. We investigated drug-drug interactions between artemether/lumefantrine and efavirenz or nevirapine.We performed a cross-over study in which HIV-infected adults received standard six-dose artemether/lumefantrine 80/480 mg before and at efavirenz or nevirapine steady state. Artemether, dihydroartemisinin, lumefantrine, efavirenz and nevirapine plasma concentrations were measured and compared.Efavirenz significantly reduced artemether maximum concentration (C(max)) and plasma AUC (median 29 versus 12 ng/mL, P?

SUBMITTER: Byakika-Kibwika P 

PROVIDER: S-EPMC3465101 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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Significant pharmacokinetic interactions between artemether/lumefantrine and efavirenz or nevirapine in HIV-infected Ugandan adults.

Byakika-Kibwika Pauline P   Lamorde Mohammed M   Mayito Jonathan J   Nabukeera Lillian L   Namakula Rhoda R   Mayanja-Kizza Harriet H   Katabira Elly E   Ntale Muhammad M   Pakker Nadine N   Ryan Mairin M   Hanpithakpong Warunee W   Tarning Joel J   Lindegardh Niklas N   de Vries Peter J PJ   Khoo Saye S   Back David D   Merry Concepta C  

The Journal of antimicrobial chemotherapy 20120611 9


<h4>Objectives</h4>Co-administration of artemether/lumefantrine with antiretroviral therapy has potential for pharmacokinetic drug interactions. We investigated drug-drug interactions between artemether/lumefantrine and efavirenz or nevirapine.<h4>Methods</h4>We performed a cross-over study in which HIV-infected adults received standard six-dose artemether/lumefantrine 80/480 mg before and at efavirenz or nevirapine steady state. Artemether, dihydroartemisinin, lumefantrine, efavirenz and nevira  ...[more]

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