Ontology highlight
ABSTRACT:
SUBMITTER: Weisberg SJ
PROVIDER: S-EPMC3465386 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Weisberg Sarah J SJ Lyakhovetsky Roman R Werdiger Ayelet-chen AC Gitler Aaron D AD Soen Yoav Y Kaganovich Daniel D
Proceedings of the National Academy of Sciences of the United States of America 20120911 39
Neurodegenerative diseases constitute a class of illnesses marked by pathological protein aggregation in the brains of affected individuals. Although these disorders are invariably characterized by the degeneration of highly specific subpopulations of neurons, protein aggregation occurs in all cells, which indicates that toxicity arises only in particular cell biological contexts. Aggregation-associated disorders are unified by a common cell biological feature: the deposition of the culprit prot ...[more]