Ontology highlight
ABSTRACT:
SUBMITTER: Rousseaux MW
PROVIDER: S-EPMC3465410 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Rousseaux Maxime W C MW Marcogliese Paul C PC Qu Dianbo D Hewitt Sarah J SJ Seang Sarah S Kim Raymond H RH Slack Ruth S RS Schlossmacher Michael G MG Lagace Diane C DC Mak Tak W TW Park David S DS
Proceedings of the National Academy of Sciences of the United States of America 20120910 39
DJ-1 mutations cause autosomal recessive early-onset Parkinson disease (PD). We report a model of PD pathology: the DJ1-C57 mouse. A subset of DJ-1-nullizygous mice, when fully backcrossed to a C57BL/6 [corrected] background, display dramatic early-onset unilateral loss of dopaminergic (DA) neurons in their substantia nigra pars compacta, progressing to bilateral degeneration of the nigrostriatal axis with aging. In addition, these mice exhibit age-dependent bilateral degeneration at the locus c ...[more]